Top2a gene
http://www.biodragon.cn/cgkt/110956.html Web2. nov 2024 · TOP2A is essential for cell division, is highly expressed during mitosis, and is required for mitotic chromosome condensation and segregation ( 13 – 16 ). Genetic …
Top2a gene
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Web23. nov 2024 · The TOP2a gene controls a network of genes that contribute to ASD. Drugs that suppress TOP2a during development can turn on a cluster of other genes that disrupt brain development and increase autism risks. Alterations to the TOP2a gene may be responsible for the social behavioral difficulties associated with ASD. • Champoux JJ (2002). "DNA topoisomerases: structure, function, and mechanism". Annual Review of Biochemistry. 70: 369–413. doi:10.1146/annurev.biochem.70.1.369. PMID 11395412. • Austin CA, Fisher LM (June 1990). "Isolation and characterization of a human cDNA clone encoding a novel DNA topoisomerase II homologue from HeLa cells". FEBS Letters. 266 (1–2): 115–117. doi:10.1016/0014-5793(90)81520-X. PMID 2163884. S2CID 46581515.
WebInterestingly, Top2a (encoding Top2α) was among the genes that were up-regulated in Top2 ... Top2a is not expressed in these cells, whereas Top2b is transcribed robustly (Fig. 1D). … Web16. dec 2024 · 我们在前面的教程：为什么一个单细胞亚群既有T细胞也有B细胞的标记基因呢，给大家演示了一种可能性，就是cycling 亚群就是 既有T细胞也有B细胞的标记基因，实 …
Web1. feb 2024 · Human cells express TOP2A and TOP2B genes, among which TOP2A is essential for cancer cell division because it is expressed at the S and M phases of the cell … WebTOP2A gene amplification and variables that were statistically significant associated with response in the univariate analysis were further evaluated in a multivariate analysis using …
Web28. feb 2024 · We therefore infer that TOP2A and other hub genes may be regarded as early biomarkers for monitoring tumor recurrence. To confirm our results, we detected the expression of TOP2A and AURKA in lung adenocarcinoma and human bronchial epithelial (HBE) cell lines. Both of these genes were downregulated in the lung adenocarcinoma cell …
Web28. feb 2024 · TOP2A gene expression in esophageal cancer tissues was higher than para-cancer tissues and was closely related to the degree of infiltration, lymph node metastasis, differentiation, and the clinical … lay-treetableWebTOP2A Gene, Drug Resistance, Tissue Distribution, Mutation Distribution, Variants, TOP2A Genome Browser, TOP2A References TOP2A - Explore an overview of TOP2A, with a … kawa concourseWebImmune cell proteome. GENERAL INFORMATIONi. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. TOP2A. laytrip holdingsWebThe clinical significance of anomalies in the gene encoding topoisomerase IIα (TOP2A) in breast cancer patients with human epidermal growth factor receptor nega kawah chinese restaurant bronxWeb28. jan 2024 · Additionally, expression of cell-cycle-related genes (e.g., PCNA, TOP2A, MKI67), OL-related genes (CNP and TCF7L2), as well as TFs are known to drive astrocyte differentiation (SOX9, NFIA, and ... kawa foods philadelphiaWeb4. jún 2013 · The significant correlation between TOP1 and TOP2A gene copy variations reinforced the molecular basis of TOP1 and TOP2A linked expression in malignant … lay train tracksWeb7. júl 2015 · TOP2A is activated by phosphorylation and enhanced by HDAC1 and HDAC2, but it is inhibited by the E3 ubiquitin ligase activity of BRCA1. SUMO modification, which is catalyzed by RanBP2, leads TOP2A to accumulate at inner centromeres and is essential for proper sister chromosome separation in mitosis. P, phosphorylation; S, SUMOylation; T, … kawa ford cena