WebChemistry of Thiophene - The Dong Group at UT Austin WebJul 15, 2024 · N, N-diethyl-7-aminocoumarin is a fluorescent mitochondria-targeting probe. In this study, a series of STAT3 inhibitors were developed by connecting N, N-diethyl-7-aminocoumarin fluorophore with benzo [b]thiophene 1, 1-dioxide moiety. All designed compounds displayed potent anti-proliferative activity against cancer cells.
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WebMar 6, 2024 · thiophene: [noun] a heterocyclic liquid C4H4S from coal tar that resembles benzene. WebThiophene 1,1-Dioxide: Synthesis, Isolation, and Properties. Oxidation of thiophene with dimethyldioxirane at −20 °C and removal of the solvent and volatile materials below −40 …
WebIn all cases, 5-aryl-4-carboxyhexahydrobenzo[b]thiophene 1,1-dioxides were also isolated. The product ratio depends on the structure of the aromatic substituent at C(5) of the spiro- adducts. The structure of 4-carboxy-5-(2-methoxyphenyl)-7-methyl -2,3,3a,4,5,6-hexahydro-benzo[b]thiophene 1,1-dioxide was confirmed by X-ray diffraction ... Webthiophene, the simplest sulfur-containing aromatic compound, with molecular formula C4H4S, which closely resembles benzene in its chemical and physical properties. It …
WebAug 21, 2024 · Due to abnormal continuous activation in tumors, inhibition of STAT3 has emerged as an attractive approach for the treatment of various cancer cells. Herein, we … WebThiophene 1,1-dioxide Molecular Formula CHOS Average mass 116.138 Da Monoisotopic mass 115.993202 Da ChemSpider ID 105377 More details: Names Properties Searches …
WebNov 1, 2024 · During enzyme kinetic studies in the presence of DTT, nucleophilic attack of a free thiol occurred with the benzo[b]thiophene 1,1-dioxide. Two representative compounds with substitution at the 5 position of the 1,3,4-oxadiazole ring, showed mixed inhibition in the absence of DTT. Incubation of these compounds with Cryptococcus IMPDH followed by ...
WebJul 27, 2015 · In this study, a series of 2-carbonylbenzo[b]thiophene 1,1-dioxide derivatives (CBT) were designed to inhibit the STAT3 SH2 domain phosphorylation site Try 705. We demonstrated that incorporation of basic flexible groups through amide bond linkage to benzo[b]thiophene 1,1-dioxide (BTP) achieved compounds with higher antiproliferative … sunshine ibootWebOct 18, 2013 · The 2,5-bis(tributylstannyl)thiophene 1,1-dioxide and a 2,5-diiodothiophene 1,1-dioxide were utilized in a series of Stille cross-coupling reactions to afford thiophene … sunshine ice cream baldwinsville nyWebOct 29, 2024 · In Chapter 2, an electron-poor thiophene derivative, 2,5-bis(tributylstannyl)thiophene 1,1-dioxide, was prepared and utilized in a series of Stille cross-coupling reactions to afford thiophene 1,1- dioxides with either electron-donating or electron-withdrawing substituents. It was found that thiophene 1,1-dioxides bearing … sunshine i love youWebThiophene, tetrahydro-, 1,1-dioxide. Related Pages. RTECS # XN0700000 CAS # 126-33-0 See: NMAM or OSHA Methods. Updated. July 2013 ... 2,3,4,5-Tetrahydrothiophene-1,1-dioxide Bondelane A Bondolane A Cyclic tetramethylene sulfone Cyclotetramethylene sulfone Dihydrobutadiene sulphone Dioxothiolan Sulfalone Sulfolan Sulfolane sunshine ice blocksWebJan 15, 2024 · 1. Introduction. Idiopathic pulmonary fibrosis (IPF), the most common type of idiopathic interstitial lung disease (ILD) [1], currently affects more than 3 million patients worldwide [2].The average survival time of the patients ranges from 2 to 4 years, which is related to the progressively exacerbating severity of IPF [3].The pathogenic mechanism of … sunshine ibstock menuhttp://gbdong.cm.utexas.edu/seminar/old/Chemistry%20of%20Thiophene%201,1-Dioxides11252014-2.pdf sunshine ice popsWebA 2,5-bis (tributylstannyl)thiophene 1,1-dioxide was prepared from 2,5-bis (trimethylsilyl)thiophene 1,1-dioxide, bis (tributyltin) oxide, and tetrabutylammonium … sunshine ice cream