Plectin网蛋白

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Webb30 aug. 2024 · Background Melanoma is a malignant tumor characterized by high proliferation and aggressive metastasis. To address the molecular mechanisms of the proto-oncogene, Rous sarcoma oncogene (Src), which is highly activated and promotes cell proliferation, migration, adhesion, and metastasis in melanoma. Plectin, a cytoskeletal … Webb12 nov. 2024 · 经蛋白组学分析，靶向肽PTP是通过与胰腺癌发生时误定位在细胞膜表面上的plectin-1特异性结合实现靶向作用的。然而，胰腺癌在遗传上是非常复杂的，肿瘤的质量是由患者的63个基因改变和12个核心信号通路的异常引起的，在不同癌症患者的肿瘤生物标志物表达中存在异质性。

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Webb8 jan. 2024 · The PLEC gene (PLEC is the acronym for plectin) is a protein-coding gene located on 8q24.3. Until 2010, this gene locus was named Plectin 1 (symbol PLEC1 in humans), and the gene product was referred to as "hemidesmosomal protein 1" or "Plectin 1, intermediate filament binding 500kDa". These designations have been replaced by … http://fund.keyanzhiku.com/Index/info/id/OTEwMDIxMTUwYmllLXNoaS1sZS1xdS1iaWUtcmVuLWppYS1wYS1zaHUtanUtYmE%3D.html dstv cheapest package

破骨细胞中plectin亚型的表达分析

WebbPlectin-1 Antibody 可检测内源水平的总网蛋白-1。根据免疫原性肽的序列，该抗体预计会与网蛋白-1 的所有同工型发生交叉反应。物种反应性：人, 猴来源/纯化使用与人网蛋 … Webbplectin 定义细胞质基质中含量丰富的一种蛋白质（300 kDa）。与多种中间丝共存，与中间丝、微管和肌球蛋白粗丝的交联和锚定有关。应用学科细胞生物学（一级学科），细胞 … WebbSubcellular localization of plectin in a myoblast and schematic representation of plectin and its binding partners, with a special focus on direct interaction partners identiﬁed in myoblasts and/or skeletal muscle. (A) Immunoﬂuorescence microscopy of a human primary myoblast using antibodies to plectin (in red) and desmin (in green). commercial wood chippers uk

(PDF) Plectin: A Cytolinker by Design - ResearchGate

Role of plectin in cytoskeleton organization and dynamics

WebbAll lanes : Anti-Plectin antibody [E398P] (ab32528) at 1/5000 dilution Lane 1 : Wild-type U-2 OS cell lysate Lane 2 : PLEC knockout U-2 OS cell lysate Lysates/proteins at 20 µg per lane. Performed under reducing conditions. Predicted band size: 532 kDa ab32528 was shown to react with PLEC in wild-type U-2 OS cells in Western blot with loss of signal observed in a … Webb19 sep. 2024 · Plectin is a giant cytoskeletal crosslinker and intermediate filament stabilizing protein. Mutations in the human plectin gene (PLEC) cause several rare diseases that are grouped under the term plectinopathies.The most common disorder is autosomal recessive disease epidermolysis bullosa simplex with muscular dystrophy … dstv choice awards winnersWebbPlektin (engl.Plectin, kurz PCN oder PLTN), auch Plectin-1 oder Hemidesmosomal protein 1 (HD1), ist ein bei Eukaryoten vorkommendes Protein.Es lässt sich im Zytoplasma nahezu aller eukaryotischen Zellen nachweisen, in großen Mengen jedoch vor allem in Muskel- und Herzmuskelzellen, Hautzellen, Nervenzellen sowie in Zellen der Plazenta. . Plektin ist ein … commercial wood chippers used

"WebbPlectin基因敲除抑制了每个器官的转移数量，并降低了整体转移负担。为了深入了解plectin在前列腺癌生长和转移中的作用，研究人员对前列腺癌plectin敲除异种移植组织进行了蛋白质组学分析。基因集富集分析表明，与细胞外基质和层粘连蛋白相互作用有关的蛋白质水平增加，而调节氨基酸代谢、细胞骨架蛋白和细胞应激反应蛋白质水平下降。 … " - Plectin网蛋白

Plectin网蛋白

Plectin is a regulator of prostate cancer growth and metastasis

WebbIdentified in complexes that contain VIM, EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, PRX and spectrin (By similarity). Interacts with COL17A1 (PubMed:12482924). 功能: Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such … Webb1 jan. 2015 · 中文摘要. 分子影像使活体、早期发现肿瘤癌变过程中的分子异常成为可能。. 研究发现Plectin-1在胰腺癌及转移灶中高表达，在正常胰腺中不表达，表明Plectin-1与胰腺癌关系密切。. 本项目选择Plectin-1为成像靶点，首先构建荧光、纳米粒双模态靶向探针，采 …

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Webbplectin expression or by expressing only rodless plectin variants, as demonstrated in EBS-MD skeletal muscles [22]. Plectin mutations in EBS-MD patients and their links on CNS abnormalities are described below in the chapter Plectin-related Pathologies of the Central Nervous System. 2. Plectin in the Central Nervous System Webb解决办法. 降低一抗浓度，增加洗膜时间和次数。. a.一抗/二抗浓度配比不合适：杂带多，大概率是抗体特异性不好，也有可能抗体浓度太高，可尝试降低一抗浓度进行实验。. b.封闭液问题：配制封闭液所用的脱脂奶粉应选用无防腐剂实验专用脱脂奶粉。. c.洗 ...

Webb30 aug. 2024 · Plectin has been widely leveraged to enhance the specificity of imaging agents and the efficacy of therapeutic modalities. Plectin-targeting peptides (PTPs) or … Webb21 mars 2024 · PLEC (Plectin) is a Protein Coding gene. Diseases associated with PLEC include Epidermolysis Bullosa Simplex 5A, Ogna Type and Muscular Dystrophy, Limb …

Webb1 okt. 1996 · In this context, it was of interest that markedly reduced or absent expression of plectin within the skin was associated with reduced staining for the 230 kDa bullous pemphigoid antigen, suggesting that the pathology of the skin may be, at least in part, a reflection of the reduction of this protein, or that plectin and the 230 kDa bullous … Webb我们确定细胞连接蛋白Plectin是Src的伙伴，并在破骨细胞中组织肌动蛋白环的形成[13]。Plectin在大脑、心脏、骨骼肌和TRAP（+）MNC中高度表达[13,14,18,19]。Plectin有13种异构体，它们之间的作用略有不同[18]。这表明，Plectin变体在每个组织中起着不同的作用。

Webb20 nov. 2024 · As plectin is a critical regulator for cell cytoarchitecture and motility, we next measured the effects of plectin knock-down on prostate cancer invasion and migration.

WebbRESEARCH PAPER Plectin deﬁciency in liver cancer cells promotes cell migration and sensitivity to sorafenib treatment Chiung-Chi Chenga, Wei-Ting Chao b, Chen-Chun Liao , Yu-Hui Tsengb, Yen-Chang Clark Laic, Yih-Shyong Laid, Yung-Hsiang Hsue, and Yi-Hsiang Liuf aDepartment of Pathology, Chang Bing Show Chwan Memorial Hospital, Lugang … commercial wood chippers for saleWebb30 juni 2024 · 存储条件-20℃以下冰冻、干燥、避光。长期保存惰性（氩气或者氮气）保护。产品化学性质PTP-PEG-DSPE磷脂-聚乙二醇-胰腺癌靶向肽PTP与胰腺癌发生时误定位在细胞膜表面上的plectin-1特异性结合实现靶向作用。本产品仅用于研究和制造用途，不能用于人类或诊断用途。 dstv choice awardsWebb30 apr. 1996 · Plectin, a 500-kDa intermediate filament binding protein, has been proposed to provide mechanical strength to cells and tissues by acting as a cross-linking element … commercial wood chipper pricesWebbPlectin is a large, widely expressed protein that crosslinks the intermediate filament and actin cytoskeleton, mechanically stabilizing cells and tissues. Plectin also plays a role in … dstv channel 215 schedule todayWebbThe cytolinker protein plectin anchors IF networks to junctional complexes, the nuclear envelope and cytoplasmic organelles and it mediates their cross talk with the actin and tubulin cytoskel-eton. These functions empower plectin to wield significant influence over IF network cytoarchitecture. Moreover, the unusual diversity of plectin isoforms dstv channels and prices 2021Webb15 sep. 2013 · Plectin is a versatile cytolinker of the plakin family conferring cell resilience to mechanical stress in stratified epithelia and muscles. It acts as a critical organizer of the cytoskeletal system by tethering various intermediate filament (IF) networks through its C-terminal IF-binding domain (IF … commercial wooden baseboard trimWebb26 nov. 2024 · 后基于胰腺癌高特异性表面分子标志物 (plectin-1)，构建高效靶向性自组装多肽纳米载体，靶向递送DNA单链损伤修复抑制剂Olaparib和DNA双链损伤修复抑制剂JQ1（如图3） [6]。图3 JQ1的“诱捕”与“杀伤”的策略 ♦ DNA折纸技术（详细内容在最后一部分） 2 纳米技术及应用国家工程研究中心 [7] 纳米技术及应用国家工程研究中心是我国 … commercial wood door with sidelight