Ionophore nigericin
WebNigericin (NSC 292567) sodium salt is an antibiotic derived from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore .Nigericin can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes. CAS No. 28643-80-3 Selleck's Nigericin (NSC 292567) sodium salt has … WebThe term ionophore (from Greek ion carrier or ion bearer) was proposed by Berton Pressman in 1967 when he and his colleagues were investigating the antibiotic …
Ionophore nigericin
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WebVaccinia virus is the prototypic member of the Orthopoxvirus genus, which also includes variola and monkeypox virus. In this study, we demonstrate that the carboxylic ionophore nigericin is a potent inhibitor of vaccinia virus replication in several human cell lines. In HeLa cells, we found that the 50% inhibitory concentration of nigericin ... Web1 dec. 2013 · The release of IL-1beta in response to nigericin, a potassium ionophore, and maitotoxin, a potent marine toxin, was also found to be dependent on cryopyrin. In contrast to Asc-/- macrophages, cells deficient in the gene encoding cryopyrin (Cias1-/-) activated caspase-1 and secreted normal levels of IL-1beta and IL-18 when infected with Gram …
Web2 dagen geleden · 3.3 IL-6 cytokine secretion in BMDM of diabetic animals stimulated with LPS and Nigericin. We have also investigated the effect of hyperglycemia concomitant with LPS+Nigericin stimulation to assess the secretion of the pro-inflammatory cytokine IL-6 ().After 2, 4, 6 and 24 hours of incubation, BMDM from diabetic and non-diabetic animals … WebThe Ca 2+ ionophore A23187 has been used extensively to permit entry of Ca 2+ into cells, which normally have a low native permeability to Ca 2+, ... Nigericin exchanges K + for protons and has been used in many studies of mitochondrial bioenergetics to alter electrical and chemical gradients for protons.
WebNigericin has been employed to study anion transport (Section 2.5) and to modify the pH gradient across energy-conserving membranes. It is often stated that nigericin abolishes ΔpH across a membrane; in fact, the ionophore equalises the K + and H + concentration gradients, with the final ion gradients depending on the experimental conditions. WebNigericin effectively causes intracellular parasites to exit their host cell within 30 min of treatment with the drug. Our results show that nigericin-induced egress depends on …
WebNigericin sodium salt acts as a potassium ionophore. It probably activates NLRP3 through the intracellular potassium (K+) efflux across the membrane [1]. Whether the formation of non‑selective pannexin-1 pores also contributes to NLRP3 activation upon … Inflammasome activation with Nano-SiO 2. NLRP3 Inflammasome Inducer - Silicon … Inflammasome activation with Hemozoin crystals. NLRP3 Inflammasome Inducer … Inflammasome activation with Alum. NLRP3 Inflammasome Inducer - Alum … Needle is a component of the type III secretion systems (T3SS) of intracellular … Rod is a component of the type III secretion systems (T3SS) of intracellular bacteria … Purified Flagellin from Pseudomonas aeruginosa.FLA-PA, a ~52 kDa protein, … Inflammasome activation with CPPD crystals. NLRP3 Inflammasome Inducer … Mincle Agonist - Synthetic analog of the cord factor. Trehalose-6,6-dibehenate …
WebProduct name Nigericin Na+ salt, K+ ionophore Description K + ionophore Biological description K + ionophore; exchanges K + for H + across most biological membranes. … phoenix contemporary homes for salehttp://www.cnreagent.com/s/sv75647.html tth westWebNigericin is a carboxylic ionophore that exchanges K + (and to a lesser extent Na +) for H + across cell membranes. If one is successful in choosing [K +] o to match [K +] i, then pH i should equal pH o. Thus, by altering pH o, one can measure the dye's spectral properties over a range of pH i values. tth youtube channelWebNigericin, an ionophore that exchanges K+ for H+ across most biologic membranes, reversibly inhibited the proliferative response of human lymphocytes to phytohemagglutinin (PHA). Inhibition occurred at nigericin concentrations of 10 (-8) M or greater, and only during the early event of mitogenesis. tti11004vp turbo teejet induction flatWebNigericin sodium salt is a potassium ionophore, exchanges K + for H + across biological membranes, in a similar manner to Valinomycin (Cat. No. 3373). Stimulates mitochondral … phoenix contractors michiganWebThe term ionophore (from Greek ion carrier or ion bearer) was proposed by Berton Pressman in 1967 when he and his colleagues were investigating the antibiotic mechanisms of valinomycin and nigericin. [4] Many ionophores are produced naturally by a variety of microbes, fungi and plants, and act as a defense against competing or pathogenic species. phoenix contact wlan 2100Web25 sep. 2024 · Human African trypanosomiasis (HAT) is caused by Trypanosoma brucei parasites. The T. brucei aquaglyceroporin isoform 2, TbAQP2, has been linked to the uptake of pentamidine. Negative membrane potentials and transmembrane pH gradients were suggested to promote transport of the dicationic antitrypanosomal drug. Application of … phoenix controls vertical sash sensor