Cisplatin electrolyte

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August undefined, 2024

WebApr 15, 2024 · Additionally, cisplatin-induced nephrotoxicity led to the unmasking of a familial form of hypomagnesemia. ... Previously, the baseline electrolyte profile was normal. He was suspected to have nephrotoxicity complicated by acute hypomagnesaemia. Hence, the boy was treated with supplementation and hypomagnesaemia recovered … WebDec 16, 2024 · Cisplatin (CDDP; cis-dichlorodiammine platinum [II]) is a non-specific drug of the cell cycle with strong cytotoxicity and broad-spectrum antitumor effects; it is widely used in urogenital system tumors, malignant lymphoma, breast cancer, head and neck cancer, non-small cell lung cancer, etc. ( 1 – 3) Cisplatin-induced nephrotoxicity is …

Profound hyponatremia and dehydration: A case of cisplatin …

WebCharacterizing the impact of magnesium and potassium-supplemented hydration with cisplatin and the subsequent electrolyte replacement requirements Characterizing the impact of magnesium and potassium-supplemented hydration with cisplatin and the subsequent electrolyte replacement requirements WebJan 12, 2024 · Platinum chemotherapy (Cisplatin), is commonly associated with electrolyte imbalances, including low magnesium (up to 90% using Cisplatin), low potassium, low phosphate, low calcium, and low sodium (up to 43%). This is the type of chemo typically used for lung, colon, ovarian, breast, head/neck, bladder, and testicular cancers. imrf and sers

Cisplatin (PIM 132) - International Programme on Chemical Safety

WebCisplatin produces moderate to severe nausea and vomiting in virtually all patients. Nausea and vomiting may start within one hour and may persist for more than 24 hours after chemotherapy. Tolerance may improve with 5-day continuous infusion as compared to rapid, intermittent IV administration. WebDrugs & Diseases cisplatin (Rx) Brand and Other Names: Classes: Antineoplastics, Alkylating; Antineoplastics, Platinum Analog Print Dosing & Uses AdultPediatricGeriatric … imrf 2023 wage cap

Electrolyte disorders with platinum-based chemotherapy ... - PubMed

Cisplatin-Induced Acute Kidney Injury and Renal Salt Wasting …

WebSep 27, 2024 · Nausea and Vomiting: cisplatin for injection can cause severe nausea and vomiting. Use highly effective antiemetic premedication [see Dosage and Administration ( 2.1) and Warnings and Precautions ( 5.3 )]. • Myelosuppression: cisplatin for injection can cause severe myelosuppression with fatalities due to infections. WebJun 8, 2024 · Cisplatin injection can cause dose-related peripheral neuropathy that becomes more severe with repeated courses of the drug. Neurologic symptoms … imrf accountWebSep 23, 2024 · Cisplatin, a platinum-based antineoplastic agent and a well-known chemotherapeutic drug is the cornerstone for the treatment of many malignancies including bladder, head and neck, lung, ovarian, and testicular cancers. It is effective against various types of cancers, including carcinomas, germ cell tumors, lymphomas, and sarcomas [ 4 ]. imrf army acronym

"WebApr 12, 2024 · As previously described, also the cisplatin can induce electrolyte imbalances. In this case, the standard approach to avoid cisplatin-induced nephrotoxicity and the consequent electrolyte alteration is the administration of IV isotonic saline solution in order to stimulate the diuresis. Some authors suggest to add 2 gr of magnesium … " - Cisplatin electrolyte

Cisplatin electrolyte

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WebMar 1, 2024 · A case of an elderly male presenting with significant recurrent hyponatremia, and prerenal azotemia, with recent exposure to cisplatin along with significant hypovolemia and urinary loss of sodium is reported. Cisplatin is a well‐known chemotherapeutic agent that can be associated with hyponatremia. It is known to be associated with a multitude … WebApparently not. It was probably due to the treatment. Also, prior to every chemo treatment, I was not only hydrated, but was given a giant bag of electrolytes, with potassium, …

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WebMay 24, 2006 · Cisplatin is a well-known nephrotoxic antineoplastic drug. Chronic hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria is one of the … WebSep 23, 2024 · Background: Cisplatin is an important drug in the treatment of various Cancers. However, this drug causes nephrotoxicity that is linked to electrolyte …

WebFeb 1, 2024 · Serum electrolytes (particularly potassium), CO 2, creatinine and BUN should be determined frequently during the first few months of Lasix therapy and periodically thereafter. Serum and urine electrolyte determinations are particularly important when the patient is vomiting profusely or receiving parenteral fluids. WebCisplatin 1. NAME 1.1 Substance 1.2 Group 1.3 Synonyms 1.4 Identification Numbers 1.4.1 CAS 1.4.2 Other Numbers 1.5 Brand Names, Trade Names 1.6 Manufacturers, Importers 1.7 Presentation, Formulation 2. SUMMARY 2.1 Main Risks and Target Organs 2.2 Summary of Clinical Effects 2.3 Diagnosis 2.4 First aid measures and management …

WebResults: We observed an increase in serum creatinine level to a peak of 1.9 mg/dL (range, 0.8 to 7.8) in the dopamine group, in comparison to 1.4 mg/dL (range, 0.9 to 3.3) in the placebo group (P = .04). Urinary magnesium excretion increased and EGF excretion decreased in both groups. WebSep 26, 2024 · While generally mild electrolyte deficiencies are pretty benign, moderate/severe abnormalities can cause many life …

WebJul 28, 2024 · Cisplatin is a platinum coordination complex chemotherapy used in the treatment of testicular, ovarian cancer, bladder, and lung cancers, as well as other …

WebAs cisplatin treatment is clinically associated with diarrhoea and 5-HT is known to be an intestinal secretagogue,16, 17 we investigated the effect of cisplatin on intestinal fluid … imrf additional contributionWebThe proteinuria associated with cisplatin nephrotoxicity is attributed to a tubular defect. 32 Hemolytic uremic syndrome has also been described, especially when cisplatin is combined with bleomycin. 33 Sequential … imrf authorized agent manualWebMay 19, 2024 · Electrolyte disorders are also related to cisplatin-induced DNA damage of thiazide-sensitive sodium-chloride co-transporter genes and to the apoptosis of distal tubule cells ( 34 ). Cisplatin treatment may … imrf annual reportWebAbstract. Cisplatin treatment causes tubulointerstitial injury to the kidneys. Common clinical syndromes associated with its use include acute renal failure and a magnesium wasting … imrf armyWebOxaliplatin Avoid cold drinks/food during administration Vincristine Loss of deep tendon reflexes Constipation Jaw Pain Paclitaxel Premedicate with Benadryl, dexamethasone and an H2-receptor blocker Etoposide Monitor for hypotension Irinotecan Major side … imrf audrey brown ryceWebApr 19, 2024 · Cisplatin + etoposide ± doxorubicin ± mitotane Carboplatin + etoposide ± doxorubicin ± mitotane Other recommended regimens Pembrolizumab ± mitotane ... imrf article 3WebSep 21, 2024 · electrolyte depletion (for example, sodium, potassium). Other important side effects include: jaundice, ringing in the ears ( tinnitus ), sensitivity to light ( photophobia ), rash, pancreatitis, nausea, diarrhea, abdominal pain, and dizziness. Increased blood sugar and uric acid levels also may occur. imrf authorized agent form